The spray may help but hand raised cats who are not taught manners by an adult cat may view the humans as 'other cats' and respond with dominance signals (which we usually miss) and attacks over territory etc.
Feliway may help.
You could choose to use soft paws on them to limit scratching ability. You can read about these here
http://www.softpaws.com/
You could try using anti anxiety meds with them to reduce their territorial aggression.
I would suggest discussing the situation with a veterinary behaviorist - you'll find some listed here or your vet may be able to refer you to one
http://www.dacvb.org/Typo3/DACVBHome/index.php
Hope this helps you!
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